The path to longevity is strongly marked by sex and gender, showing how biological and social factors interact with the exposome in shaping mortality
25 July 2025
The exposome encapsulates the cumulative environmental exposures to which individuals are exposed throughout life that shape health and mortality. By examining global populations, the chapter illuminates how detrimental factors, such as pollution and occupational hazards, accelerate aging, while protective elements, such as environment, lifestyle, and social cohesion, support healthier trajectories.
Sex and gender differences add complexity, as biological factors such as hormones and genetic susceptibilities interact with gendered behaviors and social norms to create distinct aging trajectories. Disparities persist among vulnerable subpopulations, underscoring the need for inclusive research and equitable interventions. This chapter advocates for holistic strategies to mitigate environmental risks and leverage protective factors, offering insights to improve healthspan, address disparities, and promote resilience. Integrating the exposome with the science of aging offers transformative opportunities to redefine aging and longevity globally.
Chapter in: Role of Sex and Gender in Aging and Longevity, Editor: Caruso C. Academic Press, 2025, Pages 31-54. ISBN 9780443273988
https://www.sciencedirect.com/science/article/abs/pii/B9780443273988000137
